I think by "like Larry" they meant without a family. Larry's dating Megan, true, but it's not serious yet and Larry himself has expressed disappointment that he doesn't have children ("Sniper Zero").

I don't think they see Larry as failing to thrive, they see Larry as failing to balance work and home, a failing that both Charlie and Don share.

I think it would be an unfair comparison if Larry had never expressed interest in a wife and child (because not everyone wants those things) but since he has, I don't think the comparison is unfair.